What proportion of new tuberculosis patients has a history of household tuberculosis exposure? A cross-sectional study from Udupi District, South India

Ankolekar, Vrinda Hari (2019) What proportion of new tuberculosis patients has a history of household tuberculosis exposure? A cross-sectional study from Udupi District, South India. Tropical Medicine and Infectious Disease, 4 (133). pp. 1-8. ISSN 2414-6366

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Abstract

While tuberculosis (TB) preventive therapy among household contacts is e�ective at an individual level, its population-level impact on reducing TB incidence has been unclear. In this study, we aimed to assess, among the new tuberculosis patients started on treatment between 1 October, 2018 and 30 June, 2019 in the public health facilities of Udupi district (South India): i) the proportion with a ‘history of household TB exposure’ and ii) sociodemographic and clinical factors associated with it. We conducted a cross-sectional study involving record review and patient interviews. Of 565 TB patients, 273(48%) were interviewed. Of them, 71(26%, 95% CI: 21%–32%) patients had a ‘history of household TB exposure (ever)’ with about half exposed in the past five years of diagnosis. Considering a new TB case as a proxy for incident TB, and ‘history of household TB exposure’ a proxy for household transmission, and assuming 100% e�ectiveness of preventive therapy, we may infer that a maximum of 26% of the incident cases can be prevented by giving preventive therapy to all household contacts of TB patients. In multivariable analysis, females and tobacco users had a significantly higher prevalence of household TB exposure. If there are resource constraints, these subgroups may be prioritized.

Item Type: Article
Uncontrolled Keywords: Tuberculosis preventive therapy; isoniazid preventive therapy; household contacts; operational research; SORT IT.
Subjects: Medicine > KMC Manipal > Anatomy
Depositing User: KMC Library
Date Deposited: 22 Sep 2020 06:01
Last Modified: 22 Sep 2020 06:01
URI: http://eprints.manipal.edu/id/eprint/155675

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