Reduced serum levels of cluster of differentiation 200 in Alcohol-dependent patients

Chaturvedi, Abhishek and Rao, Guruprasad and Praharaj, Samir Kumar and Kanive, Guruprasad P (2020) Reduced serum levels of cluster of differentiation 200 in Alcohol-dependent patients. Alcohol and Alcoholism, 55 (4). pp. 391-394. ISSN 0735-0414

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Abstract

Aim: Chronic alcohol consumption can activate and dysregulate the neuroimmune system which leads to neuroinflammation. Neuroimmune regulatory proteins (NIReg) (e.g. Cluster of Differentiation 200 (CD200)) are the regulators of innate immune response and are responsible for silencing the innate immunity and suppression of inflammation. In this study, we explored the changes of serum levels of CD200 in patients with alcoholic dependence at baseline, after one-week alcohol withdrawal and after one-month of alcohol abstinence. Methods: Seventeen patients with alcohol dependence admitted for de-addiction treatment and 12 healthy controls were enrolled in the study. Blood samples were collected at baseline, after oneweek, and after one-month, and CD200 levels were measured using enzyme-linked immunosorbent assay kit and compared with the healthy controls. Results: The serum level of the neuroimmune regulatory protein CD200 in alcohol dependent group (at baseline) was significantly lower compared to healthy controls (p=0.003), and increased after one-week, and one-month period. Conclusion: The present study indicates that decrease of CD200 serum levels in alcohol dependent patients and its rise during alcohol withdrawal and abstinence may provide a preliminary evidence of the role of neuroimmune regulatory proteins in neuroadaptation during alcohol withdrawal.

Item Type: Article
Subjects: Life Sciences > MLSC Manipal
Medicine > MMMC Manipal > Biochemistry
Medicine > KMC Manipal > Psychiatry
Depositing User: KMC Library
Date Deposited: 09 Oct 2020 08:26
Last Modified: 09 Oct 2020 08:26
URI: http://eprints.manipal.edu/id/eprint/155723

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