Tolerance of transcranial direct current stimulation in psychiatric dDisorders: An analysis of 2000+ sessions

Shenoy, Sonia (2020) Tolerance of transcranial direct current stimulation in psychiatric dDisorders: An analysis of 2000+ sessions. Psychiatry Research, 284. ISSN 0165-1781

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Transcranial direct current stimulation (tDCS), a non-invasive, neuromodulatory technique, is being increasingly applied to several psychiatric disorders. In this study, we describe the side-effect profile of repeated tDCS sessions ( N = 2005) that were administered to 171 patients (156 adults and 15 adolescents) with different psychiatric disorders [schizophrenia [ N = 109], obsessive-compulsive disorder [ N = 28], alcohol dependence syndrome [ N = 13], mild cognitive impairment [ N = 10], depression [ N = 6], dementia [ N = 2] and other disorders [ N = 3]]. tDCS was administered at a constant current strength of 2 mA with additional ramp-up and ramp-down phase of 20 s each at the beginning and end of the session, respectively. Other tDCS protocol parameters were: schizophrenia and obsessive-compulsive disorder: 5-days of twice-daily 20-min sessions with an inter-session interval of 3-h; Mild cognitive impairment/dementia and alcohol dependence syndrome: at least 5-days of once-daily 20-min session; Depression: 10-days of once-daily 30 min session. At the end of each tDCS session, any adverse event observed by the administrator and/or reported by the patient was systematically assessed using a comprehensive questionnaire. The commonly reported adverse events during tDCS included burning sensations (16.2%), skin redness (12.3%), scalp pain (10.1%), itching (6.7%), and tingling (6.3%). Most of the adverse events were noted to be mild, transient and well-tolerated. In summary, our observations suggest that tDCS is a safe mode for therapeutic non-invasive neuromodulation in psychiatric disorders in adults as well as the adolescent population.

Item Type: Article
Uncontrolled Keywords: TDCS; schizophrenia; obsessive compulsive disorder; depression; alcohol dependence syndrome; mild cognitive impairment; tolerance.
Subjects: Medicine > KMC Manipal > Psychiatry
Depositing User: KMC Library
Date Deposited: 09 Oct 2020 08:29
Last Modified: 09 Oct 2020 08:29

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