Biologicals to direct nanotherapeutics towards HER2-positive breast cancers

Kumar, Gautam and Nandakumar, Krishnadas and Mutalik, Srinivas and Rao, Mallikarjuna C (2020) Biologicals to direct nanotherapeutics towards HER2-positive breast cancers. Nanomedicine: Nanotechnology, Biology, and Medicine, 27. pp. 1-21. ISSN 1549-9634

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Abstract

HER2-positive breast cancer, an aggressive cancer, is treated with combinations of conventional anticancer drugs viz., cytotoxic drugs, nibs, and mAbs. Major limitations associated with this therapy are patient non-compliance due to the adverse drug reactions and rapid development of resistance by the HER2-positive malignant cells. While the former is addressed by the nano-formulations of the anticancerdrugs to some extent, the latter is still at large. This is because the nanocarriers of the anticancer drugs, by and large, lack the target specificity and selectivity. Thus, nowadays, to overcome these problems, various safe and efficacious biological agents are being used to direct the nanotherapeutics towards the HER2-positive breast cancers. The present review describes the potentials of such biological agents

Item Type: Article
Uncontrolled Keywords: Targeting ligand; Delivery strategies; Biological therapeutics; Target specificity; Nanocarriers; Multifunctional nanoparticles
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 15 Oct 2020 04:07
Last Modified: 15 Oct 2020 04:07
URI: http://eprints.manipal.edu/id/eprint/155846

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