An appraisal of current pharmacological perspectives of sesamol: A review

Bellamkonda, Bosebabu and Cheruku, Pragnya and Rao, Mallikarjuna C and Nampoothiri, Madhavan and Shenoy, Rekha R and Nandakumar, K and Kumar, Nitesh (2020) An appraisal of current pharmacological perspectives of sesamol: A review. Mini-Reviews in Medicinal Chemistry, 20 (11). pp. 988-1000. ISSN 1389-5575 (In Press)

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Abstract

Sesame (Sesamum indicum L) seeds have been authenticated for its medicinal value in both Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its main bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are emerging describing the pleiotropic biological effects of sesamol. This review summarized the most interesting in vitro and in vivo studies on the biological effects of sesamol. The present work summarises data available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated describing the pleiotropic biological effects of sesamol. Its major therapeutic effects have been elicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders. Further, compelling evidence reflected the ability of sesamol in inhibiting proliferation of the inflammatory cell, prevention of invasion and angiogenesis via affecting multiple molecular targets and downstream mechanisms. Sesamol is a safe, non‐toxic chemical that mediates anti‐inflammatory effects by down‐regulating the transcription of inflammatory markers such as cytokines, redox status, protein kinases, and enzymes that promote inflammation. In addition, sesamol also induces apoptosis in cancer cells via mitochondrial and receptor‐mediated pathways, as well as activation of caspase cascades. In the present review, several pharmacological effects of sesamol are summarised namely, antioxidant, anti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective, anti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic, wound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition, hepatoprotective activity and other biological effects. Here we have summarized the proposed mechanism behind these pharmacological effects.

Item Type: Article
Uncontrolled Keywords: Sesamol; pleiotropic sesame seed; antioxidant; anti-inflammatory; pharmacological activities.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 15 Oct 2020 04:10
Last Modified: 15 Oct 2020 04:10
URI: http://eprints.manipal.edu/id/eprint/155859

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