Efcacy and safety of inhalation budesonide in the treatment of pediatric asthma in the emergency department: a systematic review and meta‑analysis

Nandakumar, Krishnadas (2020) Efcacy and safety of inhalation budesonide in the treatment of pediatric asthma in the emergency department: a systematic review and meta‑analysis. Pharmacological Reports, 72 (4). pp. 783-798. ISSN 1734-1140

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Abstract

Background This study was aimed to evaluate the benefcial role of inhalation budesonide(BUD) in improving the pulmo�nary functions, and reducing the hospital admission rate, worsening of asthma and commonly encountered adverse events in pediatric asthma. Methods The electronic search was performed using PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials) and Google scholar databases to identify the randomized control trials(RCTs). Results 21 RCTs involving 12,787 subjects were included. The meta-analysis revealed that the BUD has reduced the hos�pitalization rate (Mantel–Haenszel (M–H), random efects odd ratio (RE-OR) of 0.34, p=0.003, I2=75%), and worsening of asthma (M–H, RE-OR 0.38, p=0.001, I2=73%); signifcantly improved the pulmonary functions such as FEV1 (Inverse variance (IV): 1.05, p<0.0001, I2=94%), PEFR (IV: 1.40, p<0.0001, I2=87%), morning PEF (IV: 1.04, p<0.0001, I2=91%), and evening PEF (IV: 1.29, p<0.0001, I2=92%) compared to control. Further, the incidences of adverse events like Pharyngitis (M–H, RE-OR 0.88, at 95% CI, p=0.69, I2=0%), Sinusitis (M–H, RE-OR 0.78, p=0.79, I2=0%), Res�piratory infections (M H, RE-OR 0.96, p=0.46, I2=0%), Otitis media (M–H, RE-OR 0.82, p=0.32, I2=12%) and Fever (M–H, RE-OR 0.78, p=0.64, I2=0%) were almost same between BUD and control. Conclusion The outcomes of the meta-analysis suggest that high-dose inhalation BUD could beneft the pediatric patients in minimizing the worsening of asthma and hospitalization rate, along with improving the pulmonary functions, with neg�ligible adverse drug reactions.

Item Type: Article
Uncontrolled Keywords: Children; Emergency department ; Hospitalization ;Budesonide ; Adverse events.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 15 Oct 2020 04:18
Last Modified: 15 Oct 2020 04:18
URI: http://eprints.manipal.edu/id/eprint/155877

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