Jose, Anmi and Shenoy, Gautham G and Rodrigues, Sunil Gabriel and Kumar, Naveena AN and Munisamy, Murali and Thomas, Levin and Rao, Mahadev (2020) Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy. Cancers, 12 (8). pp. 1-16. ISSN 2072-6694
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Abstract
Lysine-specific demethylase 5B (KDM5B/PLU1/JARID1B) is found to be overexpressed in numerous malignancies, including breast, lung, skin, liver, and prostate cancer. Identification of molecules targeting the KDM5B enzyme could be a potential lead in cancer research. Although many KDM5B inhibitors with promising outcomes have been developed so far, its further application in clinical practice is limited due to toxicity and lack of target specificity. Here, we summarize the significance of targeting KDM5B in anticancer therapy and report the molecular docking studies of some known anti-viral agents, decitabine, entecavir, abacavir, penciclovir, and 3-deazaneplanocin A in the catalytic domain JmjC of KDM5B. These studies show the repurposing potential of identified anti-viral agents in cancer therapy
Item Type: | Article |
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Uncontrolled Keywords: | Cancer; Histone modification; Inhibitor; KDM5B; Molecular docking; Repurposing |
Subjects: | Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry Pharmacy > MCOPS Manipal > Pharmacy Practice Medicine > KMC Manipal > Surgery Medicine > KMC Manipal > Surgical Oncology |
Depositing User: | KMC Library |
Date Deposited: | 15 Oct 2020 04:24 |
Last Modified: | 15 Oct 2020 04:24 |
URI: | http://eprints.manipal.edu/id/eprint/155882 |
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