Das, Torsa and Mehta, Chetan H and Nayak, Usha Y (2020) Multiple approaches for achieving drug solubility: an in silico perspective. Drug Discovery Today, 25 (7). pp. 1206-1212. ISSN 1359-6446

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Abstract

Discovering new therapeuticallyactivemolecules is theultimate destination in pharmaceutical research and development. Most drugs discovered are lipophilic and, hence, exhibit poor aqueous solubility, resulting in low bioavailability. Thus, there is a need to use various solubility enhancement techniques. Computational approaches enable the analysis of drug– carrier interactions or the numerous conformational changes in the carrier matrix that might establish an appropriate balance between cohesive and adhesive stability in a formulation. In this review, we discuss research approaches that provided molecular insight into drugs and their modifiers to unravel their solubility, stability, and bioavailability

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