Antimicrobial peptide polymers: no escape to ESKAPE pathogens—a review

Mukhopadhyay, Songhita and Bharath Prasad, AS and Mehta, Chetan Hasmukh and Nayak, Usha Y (2020) Antimicrobial peptide polymers: no escape to ESKAPE pathogens—a review. World Journal of Microbiology and Biotechnology, 36. pp. 1-14.

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Abstract

Antimicrobial resistance (AMR) is one of the significant clinical challenges and also an emerging area of concern arising from nosocomial infections of ESKAPE pathogens, which has been on the rise in both the developed and developing countries alike.These pathogens/superbugs can undergo rapid mutagenesis, which helps them to generate resistance against antimicrobials in addition to the patient’s non-adherence to the antibiotic regimen. Sticking to the idea of a ‘one- ize-fits-all’ approach has led to the inappropriate administration of antibiotics resulting in augmentation of antimicrobial resistance. Antimicrobial peptides (AMPs) are the natural host defense peptides that have gained attention in the field of AMR, and recently, synthetic AMPs are well studied to overcome the drawbacks of natural counterparts. This review deals with the novel techniques utilizing the bacteriolytic activity of natural AMPs. The effective localization of these peptides onto the negatively charged bacterial surface by using nanocarriers and structurally nanoengineered antimicrobial peptide polymers (SNAPPs) owing to its smaller size and better antimicrobial activity is also described here

Item Type: Article
Uncontrolled Keywords: Antimicrobial resistance; ESKAPE pathogens; Antimicrobial peptides; Structurally nanoengineered antimicrobial peptide polymers (SNAPPs); Nanostructured antimicrobial peptides
Subjects: Life Sciences > MLSC Manipal
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 15 Oct 2020 06:22
Last Modified: 15 Oct 2020 06:22
URI: http://eprints.manipal.edu/id/eprint/155890

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