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Anti-inflammatory and analgesic activity of Phyllanthus niruri in rodent models

Aithal Sathisha, Aithal Sathisha and Udupa Laxminarayan, Udupa Laxminarayan and *, Rathnakar U. P and Pai , Preethi Ganapathi and Acharya , Acharya Sahana Devadasa and Shastry , Rajeshwari (2009) Anti-inflammatory and analgesic activity of Phyllanthus niruri in rodent models. Indian Drugs, 46 (12).

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Abstract

This study was an attempt to explore the anti-inflammatory and analgesic activity of aqueous extract of Phyllanthus niruri in rodents. The analgesic activity of the aqueous extract (400 mg/kg and 800mg/kg) was investigated in hot-plate model, tail-flick method in rats and writhing model of mouse. Acute anti-inflammatory activity of Phyllanthus niruri was studied in rats by carrageenan induced paw edema. Cotton pellets were implanted in rats to study the effect on chronic granuloma. The aqueous extract revealed significant anti-inflammatory activity in carrageenan model (p<0.001) and chronic granuloma models (p<0.001); and analgesic activity by both central (p<0.001) and peripheral (p<0.001) mechanisms in this study. These results suggest that the aqueous extracts of Phyllanthus niruri possess analgesic and anti-inflammatory activity.

Item Type: Article
Uncontrolled Keywords: Phyllanthus niruri, paw edema, hot plate, carrageenan,
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 21 Oct 2011 11:10
Last Modified: 21 Oct 2011 11:10
URI: http://eprints.manipal.edu/id/eprint/1559

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