Prognostic Value of Melanoma‑Associated Antigen‑A (MAGE‑A) Gene Expression in Various Human Cancers: A Systematic Review and Meta‑analysis of 7428 Patients and 44 Studies

Poojary, Manish and Padacherri, Vethil Jishnu and Kabekkodu, Shama Prasada (2020) Prognostic Value of Melanoma‑Associated Antigen‑A (MAGE‑A) Gene Expression in Various Human Cancers: A Systematic Review and Meta‑analysis of 7428 Patients and 44 Studies. Molecular Diagnosis & Therapy, 24. pp. 537-555. ISSN 1177-1062

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Abstract

Background Members of the melanoma-associated antigen-A (MAGE-A) subfamily are overexpressed in many cancers and can drive cancer progression, metastasis, and therapeutic recurrence.Objective This study is the first comprehensive meta-analysis evaluating the prognostic utility of MAGE-A members in different cancers.Methods A systematic literature search was conducted in PubMed, Google Scholar, Science Direct, and Web of Science.The pooled hazard ratios with 95% confidence intervals were estimated to evaluate the prognostic significance of MAGE-A expression in various cancers. Results In total, 44 eligible studies consisting of 7428 patients from 11 countries were analysed. Univariate and multivariate analysis for overall survival, progression-free survival, and disease-free survival showed a significant association between high MAGE-A expression and various cancers (P < 0.00001). Additionally, subgroup analysis demonstrated that high MAGEA expression was significantly associated with poor prognosis for lung, gastrointestinal, breast, and ovarian cancer in both univariate and multivariate analysis for overall survival.Conclusion Overexpression of MAGE-A subfamily members is linked to poor prognosis in multiple cancers. Therefore, it could serve as a potential prognostic marker of poor prognosis in cancers

Item Type: Article
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 21 Oct 2020 10:29
Last Modified: 21 Oct 2020 10:29
URI: http://eprints.manipal.edu/id/eprint/155932

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