Prognostic role of 14q32.31 miRNA cluster in various carcinomas: a systematic review and meta-analysis

Padacherri, Vethil Jishnu and Pradyumna, Jayaram and Shukla, Vaibhav and Varghese, Vinay Koshy and Pandey, Deeksha and Sharan, Krishna and Chakrabarty, Sanjiban and Kapaettu, Satyamoorthy and Kabekkodu, Shama Prasada (2020) Prognostic role of 14q32.31 miRNA cluster in various carcinomas: a systematic review and meta-analysis. Clinical and Experimental Metastasis, 37 (1). pp. 31-46. ISSN 0262-0898

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Abstract

Deregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expression of miRNAs with the poor prognosis of cancer patients (p < 0.001). The subgroup analysis showed that lung cancer, breast cancer and papillary renal cell carcinoma (p < 0.001) have a negative association with the survival of patients. Our study is the first meta-analysis showing the association of miR-379/miR-656 cluster expression and overall survival, suggesting its potential as a prognostic indicator in multiple cancers.

Item Type: Article
Uncontrolled Keywords: Cancer; Meta-analysis; Prognostic marker; microRNA cluster; microRNA drug target
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Obstetrics & Gynaecology
Medicine > KMC Manipal > Radiotherapy and Oncology
Depositing User: KMC Library
Date Deposited: 03 Nov 2020 08:53
Last Modified: 03 Nov 2020 08:53
URI: http://eprints.manipal.edu/id/eprint/155958

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