Comparison of Chitosan-lactic Acid-poly vinyl alcohol and Chitosan-hydroxyapatite Composite Membrane as Wound Healing Accelerator

Thakur, Goutam and Pal, Kunal and Pal, Subrata and Chakraborty, Smritinath and Anis, Arfat (2019) Comparison of Chitosan-lactic Acid-poly vinyl alcohol and Chitosan-hydroxyapatite Composite Membrane as Wound Healing Accelerator. Trends in Biomaterials and Artificial Organs, 33 (2). pp. 52-55. ISSN 0971-1198

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Abstract

Wound healing is a complex biochemical process and may be promoted by moist wound dressings, which helps in maintaining a suitable micro-environment favorable for migration and proliferation of fibroblast cells. Chitosan has been used by many researchers to develop various wound healing products. The current study deals with the development of chitosan-poly (vinyl alcohol) blended membrane and chitosan-hydroxyapatite composite membrane. The membranes were prepared using lactic acid as solvent. The developed membranes were characterized for their mechanical strength hemocompatibility. Membranes demonstrated significantly different mechanical strength and hemocompatibilty. Further, preliminary results indicated that the developed membranes could be tried as wound dressing materials. The afore-mentioned membranes were used as wound dressing materials for the treatment of surgically induced wounds in matured Sprague-Dawley rats. The wound healing results indicated that the healing rate was faster with the chitosan-hydroxyapatite membrane

Item Type: Article
Subjects: Engineering > MIT Manipal > Biomedical
Depositing User: MIT Library
Date Deposited: 12 Nov 2020 04:46
Last Modified: 12 Nov 2020 04:46
URI: http://eprints.manipal.edu/id/eprint/155989

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