Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma

Shetty, Smitha Sammith and Jayaram, Pradyumna and Tanwar, Ankit Singh and Kabekkodu, Shama Prasada and Kapaettu, Satyamoorthy and Radhakrishnan, Raghu (2020) Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma. Japanese Dental Science Review, 56. pp. 97-108. ISSN 1882-7616

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Abstract

Epithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction antecedent to fibrosis in the onset of oral submucous fibrosis (OSF) and the role of EMT in its malignant transformation indicates a hitherto unexplored involvement of EMT. This review focuses on the role of EMT markers which are regulators of the EMT mediated complex network of molecular mechanisms involved in the pathogenesis of OSF and OSCC. Further the gene enrichment analysis and pathway analysis supports the association of the upregulated and downregulated genes in various EMT regulating pathways

Item Type: Article
Uncontrolled Keywords: Oral submucous fibrosis (OSF); Epithelial-mesenchymal transition (EMT); Oral squamous cell carcinoma (OSCC); Type II EMT; Signaling pathways in EMT; Transcription factors in EMT; Functional enrichment
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 03 Dec 2020 09:04
Last Modified: 03 Dec 2020 09:04
URI: http://eprints.manipal.edu/id/eprint/156049

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