Pullulan based stimuli responsive and sub cellular targeted nanoplatforms for biomedical application: Synthesis, nanoformulations and toxicological perspective

Raychaudhuri, Ruchira and Naik, Santoshi and Shreya, Ajjappla B and Kandpal, Neha and Pandey, Abhijeet and Kalthur, Guruprasad and Mutalik, Srinivas (2020) Pullulan based stimuli responsive and sub cellular targeted nanoplatforms for biomedical application: Synthesis, nanoformulations and toxicological perspective. International Journal of Biological Macromolecules, 161. pp. 1189-1205. ISSN 0141-8130

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Abstract

With growing interest in polymers of natural origin, innumerable polysaccharides have gained attention for their biomedical application. Pullulan, one of the FDA approved nutraceuticals, possesses multiple unique properties which make them highly advantageous for biomedical applications. This present review encompasses the sources, production, properties and applications of pullulan. It highlights various pullulan based stimuliresponsive systems (temperature, pH, ultrasound, magnetic), subcellular targeted systems (mitochondria,Golgi apparatus/endoplasmic reticulum, lysosome, endosome), lipid-vesicular systems (solid-lipid nanoparticles,liposomes), polymeric nanofibres, micelles, inorganic (SPIONs, gold and silver nanoparticles), carbon-based nanoplatforms (carbon nanotubes, fullerenes, nanodiamonds) and quantum dots. This article also gives insight into different biomedical, therapeutic and diagnostic applications of pullulan viz., imaging, tumor targeting,stem cell therapy, gene therapy, vaccine delivery, cosmetic applications, protein delivery, tissue engineering,photodynamic therapy and chaperone-like activities. The reviewalso includes the toxicological profile of pullulan which is helpful for the development of suitable delivery systems for clinical applications

Item Type: Article
Uncontrolled Keywords: Pullulan; Biosynthesis; Nano conjugates; Drug delivery; Imaging; Diagnostics
Subjects: Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmaceutics
Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 03 Dec 2020 09:04
Last Modified: 03 Dec 2020 09:04
URI: http://eprints.manipal.edu/id/eprint/156059

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