Prevalence of low bone mineral density in inflammatory bowel disease and factors associated with it

Khan, Zohaib AW and Shetty, Shiran and Pai, Ganesh C and Acharya, Kiran KV and Nagaraja, Ravishankar (2020) Prevalence of low bone mineral density in inflammatory bowel disease and factors associated with it. Indian journal of Gastroenterology, 39 (4). pp. 346-353. ISSN 0254-8860

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Abstract

Background Patients with inflammatory bowel disease (IBD) have numerous risk factors for low bone mineral density (BMD). We aimed to study the prevalence of low BMD in IBD and the factors associated with it.Methods BMD was measured by radial quantitative ultrasound, and clinical and biochemical characteristics were compared in prospectively enrolled patients and healthy age and gender-matched controls. Chi-square test, t test for independent samples, analysis of variance (ANOVA), Mann–Whitney U test and Kruskal–Wallis H tests were used as appropriate for univariate analysis to compare the characteristics between patients with and without abnormal BMD. Binary logistic regression analysis was done to determine the factors associated with low BMD in IBD patients.Results One hundred and six patients (Crohn’s disease [CD] = 35, ulcerative colitis [UC] = 71) and 55 controls were included. Low BMD was equally prevalent in CD, UC and controls (42.9%, 36.6%, 36.4% respectively, p = 0.791). Serum calcium and vitamin D were significantly lower in IBD patients compared to controls (p < 0.001 and p = 0.003, respectively) but not between patients with low and normal BMD.Older age (Odds ratio [OR] = 66.12 [9.299–470.243], p < 0.001), late onset of disease (OR = 4.795 [1.067–21.543],p = 0.041) and absence of steroid usage (OR = 0.272 [0.089–0.832], p = 0.022) were significantly associated with low BMD. Conclusions The prevalence of lowBMD in patients with IBD was similar to controls and this was associated with increasing age, late onset of disease, and absence of steroid usage. Judicious use of steroids can help preserve bone health in IBD

Item Type: Article
Uncontrolled Keywords: Bone densitometry; Bone health; Bone mineral density; Corticosteroid; Crohn’s disease; Dual-energy X-ray absorptiometry; Inflammatory bowel disease; Quantitative ultrasound; Radial quantitative ultrasound; Ulcerative colitis; VitaminD
Subjects: Departments at MU > Statistics
Medicine > KMC Manipal > Gastroenterology
Medicine > KMC Manipal > Orthopaedics
Depositing User: KMC Library
Date Deposited: 03 Dec 2020 09:04
Last Modified: 03 Dec 2020 09:04
URI: http://eprints.manipal.edu/id/eprint/156064

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