Risk assessment for osteoradionecrosis of the jaws in patients with head and neck cancer

Acharya, Shruthi and Pai, Keerthilatha M and Acharya, Shashidhar (2020) Risk assessment for osteoradionecrosis of the jaws in patients with head and neck cancer. Medicine and Pharmacy Reports, 93 (2). pp. 195-199. ISSN 2668-0572

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Abstract

Objectives. To identify the potential risk factors for the occurrence of osteoradionecrosis (ORN) of the jaws among patients who have been treated with radiotherapy for head and neck malignancy.Methods. The study comprised of 231 patients treated with radiotherapy for head and neck malignancy at a tertiary referral center. The following details were recorded for each patient: age, gender, histopathological diagnosis, clinical staging,tumor site, treatment modality, radiation dose, radiation field, number of fractions, type of accelerator used, radiation area and duration of follow-up . Patient’s tobacco, alcohol habit history, and history of extraction of teeth before/during/after radiotherapy were also noted.Results. Thirteen patients had osteoradionecrosis (frequency 5.62%). Among the radiotherapy variables assessed, increased radiation area was found to be significantly associated with the occurrence of osteoradionecrosis. Among the 13 ORN cases, 10 (76.9%) had a history of tobacco consumption, 8 (61.5%) had a time interval between radiotherapy and occurrence of ORN of less than 1-year duration.Conclusions. We found a low cumulative incidence of osteoradionecrosis and a tendency to occur within a year of starting radiotherapy. Patients of older age, those with a prior tobacco habit may be considered more liable to develop osteoradionecrosis. A larger radiation field may also put patients at hazard for developing osteoradionecrosis

Item Type: Article
Uncontrolled Keywords: carcinoma; Complications; Malignancy; Mandible; Necrosis; Oral cavity
Subjects: Dentistry > MCODS Manipal > Preventive and Community Dentistry
Dentistry > MCODS Manipal > Oral Medicine and Radiology
Depositing User: KMC Library
Date Deposited: 08 Jan 2021 05:39
Last Modified: 08 Jan 2021 05:39
URI: http://eprints.manipal.edu/id/eprint/156207

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