Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

Radhakrishnan, Raghu (2020) Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation. International Journal of Oral Science, 12 (1). ISSN 1674-2818

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Abstract

The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous fibrosis (OSF), oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF. While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF, the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness. The vacillating expression patterns of OM-SCMs confirm the role of keratins 5, 14, 19, CD44, β1-integrin, p63, sex-determining region Y box (SOX2), octamer-binding transcription factor 4 (Oct-4),c-MYC, B-cell-specific Moloney murine leukaemia virus integration site 1 (Bmi-1) and aldehyde dehydrogenase 1 (ALDH1) in OSF,OPMDs and OSCC. The downregulation of OM- CMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review

Item Type: Article
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Library
Date Deposited: 08 Jan 2021 05:40
Last Modified: 08 Jan 2021 05:40
URI: http://eprints.manipal.edu/id/eprint/156224

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