Elucidating the microscopic and computational techniques to study the structure and pathology of SARS-CoVs

Melanthota, Sindhoora Kaniyala and Banik, Soumyabrata and Chakraborty, Ishita and Pallen, Sparsha and Gopal, Dharshini and Chakrabarti, Shweta and Mazumder, Nirmal (2020) Elucidating the microscopic and computational techniques to study the structure and pathology of SARS-CoVs. Microscopy Research and Technique, 83 (12). pp. 1623-1638. ISSN 1059-910X

[img] PDF
00010470.pdf - Published Version
Restricted to Registered users only

Download (4MB) | Request a copy

Abstract

Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoVs), causative of major outbreaks in the past two decades, has claimed many lives all over the world. The virus effectively spreads through saliva aerosols or nasal discharge from an infected person. Currently, no specific vaccines or treatments exist for coronavirus; however, several attempts are being made to develop possible treatments. Hence, it is important to study the viral structure and life cycle to understand its functionality, activity, and infectious nature. Further, such studies can aid in the development of vaccinations against this virus. Microscopy plays an important role in examining the structure and topology of the virus as well as pathogenesis in infected host cells. This review deals with different microscopy techniques including electron microscopy, atomic force microscopy, fluorescence microscopy as well as computational methods to elucidate various prospects of this life-threatening virus.

Item Type: Article
Uncontrolled Keywords: Atomic force microscopy; computational biology; coronavirus; electron microscopy; fluorescence microscopy.
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 27 Jan 2021 12:00
Last Modified: 27 Jan 2021 12:00
URI: http://eprints.manipal.edu/id/eprint/156326

Actions (login required)

View Item View Item