Efficacy of Lignocaine with Buprenorphine versus Lignocaine in the Management of Postoperative Pain after Minor Oral Surgical Procedures:A Systematic Review and Meta-analysis

Singh, Anupam and Gadicherla, Srikanth and Smriti, Komal and Pentapati, Kalyana Chakravarthy (2020) Efficacy of Lignocaine with Buprenorphine versus Lignocaine in the Management of Postoperative Pain after Minor Oral Surgical Procedures:A Systematic Review and Meta-analysis. Journal of International Society of Preventive and Community Dentistry, 10 (6). pp. 686-691. ISSN 2231-0762

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Abstract

We aimed to review the efficacy of lignocaine with buprenorphine versus lignocaine alone in the management of postoperative pain after minor oral surgical procedures. Randomized controlled trials evaluating the efficacy of use of lignocaine with buprenorphine versus lignocaine for intra-oral procedures were included by searching multiple databases. Outcomes assessed were onset of the time of anesthesia in seconds, duration of postoperative analgesia, postoperative pain (maximal follow-up), the number of rescue analgesics required, and adverse events. The search strategy yielded 167 publications for the title and abstract screening out of which only two trials were included for full-text screening.There was considerable heterogeneity among the included studies with regards to the outcomes assessed. The need for rescue analgesics was the only outcome that was included for meta-analyses. Forest plot showed that lignocaine with buprenorphine compared to lignocaine showed a significantly lower requirement of rescue analgesics (–0.22[–2.9,–1.55]). No trial reported any adverse effects.The results show that lignocaine with buprenorphine is effective in reducing the number of rescue analgesics required by the patient

Item Type: Article
Uncontrolled Keywords: Analgesia; Anesthesia; Buprenorphine; Lignocaine; Postoperative pain; Rescue analgesics
Subjects: Dentistry > MCODS Manipal > Preventive and Community Dentistry
Dentistry > MCODS Manipal > Oral and Maxillofacial Surgery
Dentistry > MCODS Manipal > Oral Medicine and Radiology
Depositing User: KMC Library
Date Deposited: 22 Feb 2021 08:46
Last Modified: 22 Feb 2021 08:46
URI: http://eprints.manipal.edu/id/eprint/156435

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