The role of osteocalcin in mechanism of Steroid induced diabetes mellitus

Holla, Avinash and Vidyasagar, Sudha and Nandakrishna, B and Shastry, BA and Kamath, Asha and Hande, Manjunath H and Adiga, Shalini (2020) The role of osteocalcin in mechanism of Steroid induced diabetes mellitus. International Journal of Diabetes in Developing Countries, 40 (3). pp. 399-405. ISSN 0973-3930

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Background Steroids induced diabetes (SID),may be due to either insulin resistance (IR) or beta cell dysfunction or combination of both. Several studies have established that these effects of steroids may be mediated by an osteoblast derived protein called osteocalcin (OC). However, this effect has been described only in diabetic patients and has not been studied in SID patients.Aim and study design A prospective observational cohort study was designed to evaluate the correlation between serum OC level and blood glucose profile, in patients on steroids.Results Out of a total of 88 subjects who were on steroid therapy, 42(47.7%) subjects had their blood sugar levels in the diabetic range. Based on the glycemic status, subjects were divided into three groups, namely, normoglycemic, pre-diabetes and diabetes.The patients who developed SID were older than normoglycemic (mean age 43.15 vs 39.27years). The age (r=-0.105 p=0.5),BMI (r=-0.3 p= 0.07) and abdominal obesity (r=-0.32 p=0.04) were negatively correlated with serum osteocalcin in diabetes group. Serum osteocalcin level decreased as dose of steroid increased in all three groups (normogylcemic r=-0.701 p=0.004 prediabetes r=-0.3 p=0.07 diabetes -0.362 p=0.04). Fasting plasma glucose (r=-0.319 p=0.04), Fasting insulin (r=-0.10 p=0.5)and IR (r=-0.194 p=0.212) were increased with decrease in OC in patients in diabetes group.Conclusion Decrease in serum osteocalcin level with increase in glycemic parameters in steroid induced diabetes group, point to have a new role in mechanism of steroid induced diabetes. This may be a novel target to discover drugs that can maintain the OC levels so that the effect of steroids on blood sugar level can be minimised

Item Type: Article
Uncontrolled Keywords: Steroid-induced diabetes; Insulin resistance; Serumosteocalcin; Fasting insulin
Subjects: Departments at MU > Public Health
Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 12 Mar 2021 07:14
Last Modified: 12 Mar 2021 07:14

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