Photodynamic therapy to control microbial biofilms

Warrier, Anjali and Mazumder, Nirmal and Prabhu, Sudharshan and Kapaettu, Satyamoorthy and Thokur, Sreepathy Murali (2021) Photodynamic therapy to control microbial biofilms. Photodiagnosis and Photodynamic Therapy, 33. pp. 1-6. ISSN 1572-1000

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Abstract

Microorganisms thrive in well-organized biofilm ecosystems. Biofilm-associated cells typically show increased resistance to antibiotics and contribute significantly to treatment failure. This has prompted investigations aimed at developing advanced and novel antimicrobial approaches that could effectively overcome the shortcomings associated with conventional antibiotic therapy. Studies are ongoing to develop effective curative strategies ranging from the use of peptides, small molecules, nanoparticles to bacteriophages, sonic waves, and light energy targeting various structural and physiological aspects of biofilms. In photodynamic therapy, a light source of a specific wavelength is used to irradiate non-toxic photosensitizers such as tetrapyrroles, synthetic dyes or,naturally occurring compounds to generate reactive oxygen species that can exert a lethal effect on the microbe especially by disrupting the biofilm. The photosensitizer preferentially binds to and accumulates in the microbial cells without causing any damage to the host tissue.Currently, photodynamic therapy is increasingly being used for the treatment of oral caries and dental plaque, chronic wound infections, infected diabetic foot ulcers, cystic fibrosis, chronic sinusitis, implant device-associated infections, etc. This approach is recognized as safe, as it is non-toxic and minimally invasive, making it a reliable, realistic, and promising therapeutic strategy for reducing the microbial burden and biofilm formation in chronic infections. In this review article, we discuss the current and future potential strategies of utilizing photodynamic therapy to extend our ability to impede and eliminate biofilms in various medical conditions

Item Type: Article
Uncontrolled Keywords: Antibiotics; Biofilm; Chronic infections; Photodynamic therapy; Photosensitizers
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 01 Jun 2021 08:57
Last Modified: 01 Jun 2021 08:57
URI: http://eprints.manipal.edu/id/eprint/156729

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