The potency of heterocyclic curcumin analogues: An evidence-based review

Rodrigues, Fiona C and Kumar, Anil N V and Thakur, Goutam (2021) The potency of heterocyclic curcumin analogues: An evidence-based review. Pharmacological Research. ISSN 1043-6618

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Curcumin, a potent phytochemical, has been a significant lead compound and has been extensively investigated for its multiple bioactivities. Owing to its natural origin, non-toxic, safe, and pleiotropic behavior, it has been extensively explored. However, several limitations such as its poor stability, bioavailability, and fast metabolism prove to be a constraint to achieve its full therapeutic potential. Many approaches have been adopted to improve its profile, amongst which, structural modifications have indicated promising results. Its symmetric structure and simple chemistry have prompted organic and medicinal chemists to manipulate its arrangement and study its implications on the corresponding activity. One such recurring and favorable modification is at the diketo moiety with the aim to achieve isoxazole and pyrazole analogues of curcumin. A modification at this site is not only simple to achieve, but also has indicated a superior activity consistently. This review is a comprehensive and wide-ranged report of the different methods adopted to achieve several cyclized curcumin analogues along with the improvement in the efficacy of the corresponding activities observed.

Item Type: Article
Uncontrolled Keywords: Curcumin Structural modification Analogues Diketo Heterocyclic Cyclization
Subjects: Engineering > MIT Manipal > Biomedical
Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 29 Jun 2021 09:34
Last Modified: 29 Jun 2021 09:34

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