Lifestyle modification with physical activity promotion on leptin resistance and quality of life in metabolic syndrome - A systematic review with Meta-analysis

Anche, Parameshwar and Maiya, Arun G and Kamath, Shobha U and Shastry, Ananthakrishna Barkur and Ravishankar, N (2020) Lifestyle modification with physical activity promotion on leptin resistance and quality of life in metabolic syndrome - A systematic review with Meta-analysis. Current Diabetes Reviews, 16 (3). pp. 1-11. ISSN 1573-3998

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Abstract

Objective: This study focused to systematically extract, summarize and analyse the data on the effect of lifestyle modification on leptin resistance and quality of life in metabolic syndrome. Methods: The systematic search was done using PubMed, Cochrane Database, EMBASE, Science Direct, CINAHL, Springer link, Web of Science from 2000-2018. English language articles and quantitative studies focusing on leptin resistance and quality of life were included. Random effect analysis was adopted to pool data and estimate 95% CI. The meta-analysis was done separately for leptin resistance and quality of life which included a total of 9 studies on both RCTs and Non-RCTs. Results: The meta-analysis of RCTs reported insignificant effect of lifestyle modification on leptin resistance in metabolic syndrome when compared to comparison group [-5.94[-14.28, 2.41]. Two clinical trials showed a significant effect with pooled data [5.52[2.14, 8.91]. Meta-analysis of RCTs focusing on quality of life showed significant effect on mental component [4.89 [0.16, 9.62] of quality of life [2.36 [-3.67, 8.39] when compared to comparison group. Conclusion: This meta-analysis suggested that lifestyle modification has a potential to improve leptin resistance and mental component of quality of life in metabolic syndrome. However, more clearly defined studies require a firmer conclusion.

Item Type: Article
Uncontrolled Keywords: Metabolic Syndrome; lifestyle modification; physical activity promotion; leptin resistance; quality of life.
Subjects: Allied Health > MCOAHS Manipal > Physiotherapy
Medicine > KMC Manipal > Biochemistry
Departments at MU > Public Health
Medicine > KMC Manipal > Medicine
Depositing User: KMC Library
Date Deposited: 01 Jun 2021 08:55
Last Modified: 01 Jun 2021 08:55
URI: http://eprints.manipal.edu/id/eprint/156757

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