SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study

Krishnaprasad, Baby and Maity, Swastika and Mehta, Chetan H and Suresh, Akhil and Nayak, Usha Y and Nayak, Yogendra (2021) SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study. European Journal of Pharmacology, 896. pp. 1-11. ISSN 0014-2999

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Abstract

The coronavirus disease (COVID-19) is spreading between human populations mainly through nasal droplets.Currently,the vaccines have great hope, but it takes years for testing its efficacy in human. As there is no specific drug treatment available for COVID-19 pandemic, we explored in silico repurposing of drugs with dual inhibition properties by targeting transmembrane serine protease 2 (TMPRSS2) and human angiotensin-converting enzyme 2 (ACE2) from FDA-approved drugs.The TMPRSS2 and ACE2 dual inhibitors in COVID-19 would be a novel antiviral class of drugs called “entry inhibitors.For this purpose, approximately 2800 US-FDA approved drugs were docked using a virtual docking tool with the targets TMPRSS2 and ACE2. The best-fit drugs were selected as per docking scores and visual outcomes. Later on, drugs were selected on the basis of molecular dynamics simulations. The drugs alvimopan, arbekacin, dequalinum, fleroxacin, lopinavir, and valrubicin were shortlisted by visual analysis and molecular dynamics simulations. Among these, lopinavir and valrubicin were found to be superior in terms of dual inhibition. Thus, lopinavir and valrubicin have the potential of dual-target inhibition whereby preventing SARS-CoV-2 entry to the host. For repurposing of these drugs, further screening in vitro and in vivo would help in exploring clinically

Item Type: Article
Uncontrolled Keywords: SARS-CoV-2; Homology modelling; Molecular docking; Repurposing; TMPRSS2; ACE2
Subjects: Departments at MU > Public Health
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 09 Jun 2021 04:25
Last Modified: 09 Jun 2021 04:25
URI: http://eprints.manipal.edu/id/eprint/156792

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