Efect of physical activity promotion on adiponectin, leptin and other infammatory markers in prediabetes: a systematic review and meta‑analysis of randomized controlled trials

Jadhav, Radhika and Maiya, Arun G and Shashikiran, U and Shivashankara, KN (2021) Efect of physical activity promotion on adiponectin, leptin and other infammatory markers in prediabetes: a systematic review and meta‑analysis of randomized controlled trials. Acta Diabetologica, 58 (4). pp. 419-429. ISSN 0940-5429

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Abstract

Aims Infammatory stage in prediabetes is associated with increase in level of adipokines and pro-infammatory cytokines. Physical activity promotion considered as a frst-line therapeutic strategy to treat prediabetes. We have conducted the systematic review and meta-analysis to strengthen the evidence on the impact of physical activity promotion on infammatory markers in prediabetes. Methods Studies were identifed using electronic search and manual search techniques by choosing keywords for prediabetes, physical activity and infammatory marker. Randomized controlled trials on individuals diagnosed with prediabetes and provided intervention in the form of physical activity were included in this review. Adiponectin, leptin, C-reactive protein, interleukin-6 and tumour necrosis factor-α were the considered outcome measures. Results Our search retrieved 1,688 citations, 31 full-text articles assessed for eligibility of inclusion. Nine studies satisfed the pre-specifed criteria for inclusion. Meta-analysis found that physical activity with or without dietary or lifestyle modifcation reduces level of leptin (MD−2.11 ng/mL, 95% CI −3.81 – −0.42) and interleukin-6 (MD −0.15 pg/mL, 95% CI −0.25–−0.04). It has no efect on level of adiponectin (MD 0.26 µg/mL, 95% CI −0.42– 0.93), C-reactive protein ( −0.05 mg/L, 95% CI −0.33–0.23) and tumour necrosis factor-α (MD 0.67 pg/mL, 95% CI −2.56–3.89). Conclusions This review suggests that physical activity promotion with dietary and lifestyle modifcation may reduce the level of leptin and interleukin-6 but are uncertain if there is any efect on levels of adiponectin, C-reactive protein and tumour necrosis factor-α in the individuals with prediabetes.

Item Type: Article
Uncontrolled Keywords: Diabetes; lifestyle; infammation; cytokines; adipokines.
Subjects: Allied Health > MCOAHS Manipal > Physiotherapy
Medicine > KMC Manipal > Medicine
Depositing User: KMC Library
Date Deposited: 15 Jun 2021 06:30
Last Modified: 15 Jun 2021 06:30
URI: http://eprints.manipal.edu/id/eprint/156846

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