Mechanistic targets for BPH and prostate cancer–a review

Shah, Abhishek and Shah, Aarti Abhishek and Nandakumar, K and Lobo, Richard (2020) Mechanistic targets for BPH and prostate cancer–a review. Reviews on Environmental Health. pp. 1-10. ISSN 0048-7554

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Abstract

All men, almost, suffer from prostatic disorders in average life expectancy. In the year of 1950s, the first autopsy of prostate gland discovered the link between Benign prostatic hyperplasia (BPH) and Prostate Cancer (PCa). After that, many histology, biochemistry, epidemiology studies explained the association and associated risk factor for the same. From the various scientific evidence, it is proved that both diseases share some common transcription factors and signalling pathways. Still, BPH cannot be considered as the first step of PCa progression. To define, the relationship between both of the diseases, a well-defined large epidemiological study is needed. Along with androgen signalling, imbalanced apoptosis, oxidative stress, and microbial infection also crucial factors that significantly affect the pathogenesis of BPH. Various signalling pathways are involved in the progression of BPH. Androgen signalling is the driving force for the progress of PCa. In PCa androgen signalling is upregulated as compared to a healthy prostate. Some dominant Androgen-regulated genes and their functions have been discussed in this work.

Item Type: Article
Uncontrolled Keywords: Androgen signalling; BPH; FKBP5; prostate cancer; TGF β signalling.
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 27 Jun 2021 05:57
Last Modified: 27 Jun 2021 05:57
URI: http://eprints.manipal.edu/id/eprint/156861

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