Application of adipose tissue stem cells in regenerative dentistry: A systematic review

Gaur, Sumit and Agnihotri, Rupali (2021) Application of adipose tissue stem cells in regenerative dentistry: A systematic review. Journal of International Society of Preventive and Community Dentistry, 11 (3). pp. 266-271. ISSN 2231-0762

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Abstract

Aim: The aim of this study was to systematically review the applications of adipose tissue stem cells (ADSCs) in regenerative dentistry. Materials and Methods: An lectronic search was conducted in Medline (PubMed) and Scopus databases. The original research associated with the role of ADSCs in regeneration of alveolar bone, periodontal ligament (PDL), cementum as well as the dental pulp was evaluated. Among the included studies, three animal studies and one human study had low risk of bias. Results: A total of 33 relevant studies were included in the review. The animal models, in vivo human, and in vitro studies revealed that ADSCs had a significant osteogenic differentiation potential. Besides, they had potential to differentiate into PDL, cementum, and dental pulp tissue. Conclusion: The ADSCs may be specifically applied for bone tissue engineering in the management of alveolar bone defects, specifically in dental implants and periodontal disease. However, their role in regeneration of PDL, cementum, and dental pulp requires further investigations. Overall, their applications in regenerative dentistry needs further verification through human clinical trials.

Item Type: Article
Uncontrolled Keywords: Adipose tissue stem cells; bone, cementum; periodontal ligament; pulp; regeneration; tissue engineering.
Subjects: Dentistry > MCODS Manipal > Pedodontics and preventive Dentistry
Dentistry > MCODS Manipal > Periodontology
Depositing User: KMC Library
Date Deposited: 01 Jul 2021 10:02
Last Modified: 01 Jul 2021 10:02
URI: http://eprints.manipal.edu/id/eprint/156914

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