A review on human body fluids for the diagnosis of viral infections: scope for rapid detection of COVID-19

Adigal, Sphurti S and Rayaroth, Nidheesh V and John, Reena V and Pai, Keerthilatha M and Bhandari, Sulatha and Mohapatra, Aswini Kumar and Lukose, Jijo and Patil, Ajeetkumar and Bankapur, Aseefhali and Chidangil, Santhosh (2021) A review on human body fluids for the diagnosis of viral infections: scope for rapid detection of COVID-19. Expert Review of Molecular Diagnostics, 21 (1). pp. 31-42. ISSN 1473-7159

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Introduction: The unprecedented outbreaks of corona virus disease of 2019 (COVID-19) have highlighted the necessity of readily available, reliable, precise, and faster techniques for its detection. Nasopharyngeal swab has been the gold standard for the diagnosis of COVID-19. However, it is not an ideal screening procedure for massive screening as it implicates the patient’s stay in the hospital or at home until diagnosis, thus causing crowding of the specimen at the diagnostic centers. Present study deal with the exploration of potential application of different body fluids using certain highly objective techniques (Optical and e-Nose) for faster detection of molecular markers thereby diagnosing viral infections. Areas covered: This report presents an evaluation of different body fluids, and their advantages for the rapid detection of COVID-19, coupled with highly sensitive optical techniques for the detection of molecular biomarkers. Expert opinion: Tears, saliva, and breath samples can provide valuable information about viral infections. Our brief review strongly recommends the application of saliva/tears and exhaled breath as clinical samples using technics such as high-performance liquid chromatography-laser-induced fluorescence, photoacoustic spectroscopy, and e-Nose, respectively, for the fast diagnosis of viral infections.

Item Type: Article
Uncontrolled Keywords: Body fluids; photonics; HPLC-LIF; photo-acoustic spectroscopy; COVID-19.
Subjects: Dentistry > MCODS Manipal > Oral Medicine and Radiology
Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Ophthalmology
Medicine > KMC Manipal > Pulmonary Medicine
Depositing User: KMC Library
Date Deposited: 13 Jul 2021 10:32
Last Modified: 13 Jul 2021 10:32
URI: http://eprints.manipal.edu/id/eprint/156977

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