High dose thiamine strategy in wernicke–korsakoff syndrome and related thiamine deficiency conditions associated with alcohol use disorder

Praharaj, Samir Kumar and Munoli, Ravindra N and Shenoy, Sonia and Udupa, Suma T and Thomas, Linda Susan (2021) High dose thiamine strategy in wernicke–korsakoff syndrome and related thiamine deficiency conditions associated with alcohol use disorder. Indian Journal of Psychiatry, 63 (2). pp. 121-126. ISSN 0019-5545

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Abstract

Thiamine is essential for the activity of several enzymes associated with energy metabolism in humans. Chronic alcohol use is associated with deficiency of thiamine along with other vitamins through several mechanisms. Several neuropsychiatric syndromes have been associated with thiamine deficiency in the context of alcohol use disorder including Wernicke–Korsakoff syndrome, alcoholic cerebellar syndrome, alcoholic peripheral neuropathy, and possibly, Marchiafava–Bignami syndrome. High‑dose thiamine replacement is suggested for these neuropsychiatric syndromes.

Item Type: Article
Uncontrolled Keywords: Alcohol use disorder; alcoholic cerebellar syndrome; alcoholic peripheral neuropathy; Marchiafava–Bignami syndrome; thiamine; Wernicke–Korsakoff syndrome.
Subjects: Medicine > KMC Manipal > Psychiatry
Depositing User: KMC Library
Date Deposited: 13 Jul 2021 10:32
Last Modified: 13 Jul 2021 10:32
URI: http://eprints.manipal.edu/id/eprint/156998

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