Sirtuins, a potential target in Traumatic Brain Injury and relevant experimental models

Ranadive, Niraja and Nampoothiri, Madhavan and Mudgal, Jayesh (2021) Sirtuins, a potential target in Traumatic Brain Injury and relevant experimental models. Brain Research Bulletin, 171. pp. 135-141. ISSN 0361-9230

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Abstract

Traumatic brain injury (TBI) can simply be defined as a violent external injury to the head causing brain dysfunction. The primary injury occurs immediately on impact whereas the secondary injury begins minutes to months after impact. TBI affects a vast majority of population worldwide yet, there isn’t any therapeutic intervention available. Sirtuins (SIRTs) are important regulator proteins found in humans. In several neurodegenerative diseases, SIRTs have proven its neuroprotective actions. Owing to the pathophysiological similarities in these diseases and TBI, SIRTs may serve as a potential target for therapeutic intervention in TBI. This review aims to describe the relevance of SIRTs as a potential pharmacological target in TBI. Also, the experimental animal model of TBI explored to understand the role of SIRTs in TBI have been discussed

Item Type: Article
Uncontrolled Keywords: Traumatic brain injury; Sirtuins; Neuroinflammation; Glial cell activation
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 13 Jul 2021 10:33
Last Modified: 13 Jul 2021 10:33
URI: http://eprints.manipal.edu/id/eprint/157010

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