Kumari, Rashmi and Sunil, Dhanya (2021) A mechanistic insight into benefits of aggregation induced emissive luminogens in cancer. Journal of Drug Targeting, 29 (6). pp. 592-608. ISSN 1061-186X

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Abstract

Exploration of advanced chemotheranostics that benefit from a combined in vivo strategy of cancer diag�nosis and chemotherapy simultaneously is highly valued and will expose novel possibilities in modifying treatment and reduce side effects. In recent years, nanodrug delivery systems that incorporate aggrega�tion-induced emissive luminogens (AIEgens) have been developed to track and monitor anticancer drug release, trace translocation processes and predict chemotherapeutic responses. There are several classes of AIEgen based chemotheranostics such us stimuli-responsive nanoprodrugs, pH-sensitive mesoporous silica nanocarriers, supramolecular polymer systems, drug encapsulated carriers, carrier-free nanodrugs, self-indi�cating drug delivery nanomachines and AIEgen-prodrug co-assembly. The present review conveys mech�anistic insight into the benefits of AIEgens in the theranostic application by illustrating the recent breakthroughs in chemotheranostic nanomedicines that incorporate these unique fluorophores as signal reporters. The perspectives that can be further explored are also highlighted with the hope to instil more research interest in the advancement of AIE active cancer chemotheranostics for imaging and treat�ment in vivo

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