Small interfering RNAs (siRNAs) based gene silencing strategies for the treatment of glaucoma: Recent advancements and future perspectives

Naik, Santoshi and Shreya, AB and Raychaudhuri, Ruchira and Pandey, Abhijeet and Lewis, Shaila A and Hazarika, Manali and Bhandary, Sulatha V and Rao, Satish BS and Mutalik, Srinivas (2021) Small interfering RNAs (siRNAs) based gene silencing strategies for the treatment of glaucoma: Recent advancements and future perspectives. Life Sciences, 264. pp. 1-19. ISSN 0024-3205

[img] PDF
12876.pdf - Published Version
Restricted to Registered users only

Download (748kB) | Request a copy

Abstract

RNA-interference-based mechanisms, especially the use of small interfering RNAs (siRNAs), have been under investigation for the treatment of several ailments and have shown promising results for ocular diseases including glaucoma. The eye, being a confined compartment, serves as a good target for the delivery of siRNAs.This review focuses on siRNA-based strategies for gene silencing to treat glaucoma. We have discussed the ocular structures and barriers to gene therapy (tear film, corneal, conjunctival, vitreous, and blood ocular barriers),methods of administration for ocular gene delivery (topical instillation, periocular, intracameral, intravitreal,subretinal, and suprachoroidal routes) and various viral and non-viral vectors in siRNA-based therapy for glaucoma. The components and mechanism of siRNA-based gene silencing have been mentioned briefly followed by the basic strategies and challenges faced during siRNA therapeutics development. We have emphasized different therapeutic targets for glaucoma which have been under research by scientists and the current siRNAbased drugs used in glaucoma treatment. We also mention briefly strategies for siRNA-based treatment after glaucoma surgery

Item Type: Article
Uncontrolled Keywords: RNA interference; Gene silencing; siRNA; Glaucoma
Subjects: Medicine > KMC Manipal > Ophthalmology
Pharmacy > MCOPS Manipal > Pharmaceutics
Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 25 Aug 2021 08:33
Last Modified: 25 Aug 2021 08:33
URI: http://eprints.manipal.edu/id/eprint/157179

Actions (login required)

View Item View Item