Evaluation and monitoring of response to platelet transfusion therapy: experience from a tertiary care center

Chenna, Deepika and Shastry, Shamee and Baliga, Poornima (2021) Evaluation and monitoring of response to platelet transfusion therapy: experience from a tertiary care center. Acta Clinica Belgica, 76 (4). pp. 300-303. ISSN 0001-5512

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Objective: Refractoriness to platelet transfusion is defined as Corrected Count Increment (CCI) <5000 after two sequential ABO identical transfusions. Immune causes include alloimmunization to HLA and/or platelet-specific antigens. Analysis of various factors leading to platelet refractoriness would help in the management of the patient in a timely manner. Materials and Methods: A prospective observational study on platelet transfusions from November 2013 to June 2015 was conducted. Demographic information, pre, and posttransfusion platelet counts and relevant clinical details were noted. Among patients who were considered refractory to platelet transfusions, platelet factor 3 assay was performed to detect antiplatelet antibodies. Data were analyzed using SPSS software. A P value of <0.05 was considered to be statistically significant.Results: A total of 1190 patients received platelet transfusions during the study period. Among these only 339 (28.5%) patients received transfusions on two or more occasions, of which 237 (69.91%) were considered non-refractory. Among the 102 (30.1%) refractory cases non-immune causes for refractoriness were present in 97 (95.1%) patients and antiplatelet antibody was positive in 18 (17.64%) patients. Bleeding and medication have shown to have significantly contributed to refractoriness (p = 0.025 and 0.003) respectively. Use of medication was independently associated with refractoriness.Conclusion: Non-immune causes are more profound in leading to a poor response to platelet transfusions. Recognizing the cause of poor response and treating the underlying cause would help in getting a better response

Item Type: Article
Uncontrolled Keywords: Platelet transfusion; Platelet function test; Thrombocytopenia; Refractoriness; Platelet count; Platelet activation
Subjects: Medicine > KMC Manipal > Immunohematology and Blood Transfusion
Depositing User: KMC Library
Date Deposited: 27 Aug 2021 08:35
Last Modified: 27 Aug 2021 08:35
URI: http://eprints.manipal.edu/id/eprint/157222

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