Shetty, Smitha Sammith and Radhakrishnan, Raghu (2021) Role of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis. Archives of Oral Biology, 128. pp. 1-7. ISSN 0003-9969
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Abstract
Objective(s): The objective of the present manuscript is to elucidate the role of matrix stiffness in the malignant transformation of oral submucous fibrosis. Design: The role of matrix stiffness in several cancers including oral cancer was reviewed with a tailored search strategy using relevant keywords as per the Medline format. The role of molecular mediators, Yes-associated protein 1 (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) was weighed in the context of OSF along two distinct pathways. Results: Increased matrix stiffness activates the transcriptional coactivators, YAP and TAZ shuttling between the nucleus and cytoplasm. YAP and TAZ, serve as mechanical transducers in promoting cell migration, invasion and epithelial-mesenchymal transition (EMT). The hypoxic microenvironment in the advanced stage of OSF promotes the migratory phenotype through mechanical memory. Conclusions: Reprogramming of a stiff matrix has the potential to restore the Hippo-YAP/TAZ tumor suppressor pathway and reverse fibrosis-associated tumor development.
Item Type: | Article |
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Uncontrolled Keywords: | Matrix stiffness; oral submucous fibrosis; oral cancer; hippo pathway; cellular senescence. |
Subjects: | Dentistry > MCODS Manipal > Oral Pathology and Microbiology |
Depositing User: | KMC Library |
Date Deposited: | 08 Sep 2021 10:35 |
Last Modified: | 08 Sep 2021 10:35 |
URI: | http://eprints.manipal.edu/id/eprint/157237 |
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