Khan, Nadeem Ghani and Correia, Jacinta and Adiga, Divya and Rai, Padmalatha Satwadi and Dsouza, Herman Sunil and Chakrabarty, Sanjiban and Kabekkodu, Shama Prasada (2021) A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence. Environmental Science and Pollution Research, 28. pp. 19643-19663. ISSN 0944-1344

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Abstract

Bisphenol A [BPA; (CH3)2C(C6H4OH)2] is a synthetic chemical used as a precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances of human exposure and predisposing individuals at extremely low doses to diseases, including cancer. It enters the human body via oral, inhaled, and dermal routes as leach-out products. BPA may be anticipated as a probable human carcinogen. Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA. Furthermore, BPA exerts its toxicological effects at the genetic and epigenetic levels, influencing various cell signaling pathways. The present review summarizes the available data on BPA and its potential impact on cancer and its clinical outcome

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