Lacidipine: review of analytical methods developed for pharmaceutical dosage forms and biological fluids

Chebrolu, Sai Tejasvini and Kumar, Lalit and Verma, Ruchi (2021) Lacidipine: review of analytical methods developed for pharmaceutical dosage forms and biological fluids. Bioanalysis, 13 (12). pp. 1011-1024. ISSN 1757-6180

[img] PDF
RMS - 00012438.pdf - Published Version
Restricted to Registered users only

Download (604kB) | Request a copy

Abstract

Lacidipine (LAC) is a calcium antagonist used in the treatment of hypertension. It is a lipophilic drug containing dihydropyridine ring that is responsible for the activity. This review article gives an overview of various analytical techniques proposed for the determination of LAC in pharmaceutical dosage forms, in pure form, in biological fluids and to determine characteristics of LAC in modified release dosage forms. Ultra violet/visible spectrophotometric, spectroflourimetric, high performance liquid chromatography, high performance thin layer chromatography, electro-analytical, bioanalytical and miscellaneous methods such as microbiological assay, X-ray diffraction, differential scanning calorimetry, were discussed. Various parameters such as system suitability, selectivity, linearity, precision, accuracy, limit of detection, limit of quantification and robustness have been discussed for the employed methods.

Item Type: Article
Uncontrolled Keywords: Analytical methods; biological fluids; lacidipine; pharmaceutical dosage forms.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 08 Sep 2021 10:33
Last Modified: 08 Sep 2021 10:33
URI: http://eprints.manipal.edu/id/eprint/157253

Actions (login required)

View Item View Item