Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems

Bhaskaran, Navya Ajitkumar and Kumar, Lalit (2021) Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems. Journal of Controlled Release, 336. pp. 16-39. ISSN 0168-3659

[img] PDF
12439.pdf - Published Version
Restricted to Registered users only

Download (820kB) | Request a copy

Abstract

Regardless of progress in therapy management which are developed for colon cancer (CC), it remains the third most common cause of mortality due to cancers around the world. Conventional medicines pose side effects due to untoward action on non-target cells. Their inability to deliver drugs to the affected regions of the colon locally,in a reproducible manner raises a concern towards the efficacy of therapy. In this regard, nanoparticles emerged as a promising drug delivery system due to their flexibility in designing, drug release modulation and cancer cell targeting. Not only are nanoparticles making their way into colon cancer research in the revolution of conventional onco-therapeutics, but they also offer promising scope in the development of colon cancer vaccines and theranostic tools. However, there are challenges with respect to drug delivery using nanoparticles, which may hamper the delivery of these novel carriers to the colon. The present review addresses recent advents in nanotechnology for colon-specific drug delivery (CDDS) which may help to overcome the existing challenges and intends to recognize futuristic potentials in the treatment of CC with CDDS

Item Type: Article
Uncontrolled Keywords: Colon cancer; Nanoparticles; Oncotherapeutics; Colon-specific drug delivery
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 08 Sep 2021 10:33
Last Modified: 08 Sep 2021 10:33
URI: http://eprints.manipal.edu/id/eprint/157272

Actions (login required)

View Item View Item