Hepato‐protective role of chemo‐preventive probiotics during DMH‐induced CRC in rats

Kamal, Rozy (2021) Hepato‐protective role of chemo‐preventive probiotics during DMH‐induced CRC in rats. Journal of Biochemical and Molecular Toxicology, 35 (7). pp. 1-7. ISSN 1095-6670

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The aim of the study was to assess the hepatotoxicity, and therefore pharmacological safety of probiotics Lactobacillus plantarum (AdF10) and Lactobacillus rhamnosus GG (LGG) for potential use in colorectal cancer (CRC) prevention. Thirty‐six female Sprague Dawley (SD) rats were divided into six groups: normal control, AdF10‐ treated, LGG treated, 1,2‐Dimethyl hydrazine (DMH)‐treated, AdF10 + DMH‐ treated, and LGG + DMH‐treated groups. Antioxidant enzyme activity, lipid proxidation, and liver function were assessed. Administration of probiotics in both AdF10 + DMH‐treated and LGG + DMH‐treated groups downregulated DMH induced a rise in lipid peroxide (LPO), glutathione reductase (GR) activity, and increased the diminished glutathione reduced (GSH) content and catalase (CAT), glutathione‐transferase (GST), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities. DMH‐treated rats receiving the probiotic treatment suffered less liver damage when compared with rats that did not receive probiotics. In conclusion, the study identifies the use of probiotics as an effective and nontoxic chemo‐preventive interventional in CRC.

Item Type: Article
Uncontrolled Keywords: 99mTc‐mebrofenin; antioxidants; liver injury; probiotics.
Subjects: Allied Health > MCOAHS Manipal > Nuclear Medicine
Depositing User: KMC Library
Date Deposited: 08 Sep 2021 10:32
Last Modified: 08 Sep 2021 10:32
URI: http://eprints.manipal.edu/id/eprint/157304

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