Jha, Adrija and Nikam, Ajinkya Nitin and Kulkarni, Sanjay and Mutalik, Sadhana P and Pandey, Abhijeet and Hegde, Manasa and Rao, Satish BS and Mutalik, Srinivas (2021) Biomimetic nanoarchitecturing: A disguised attack on cancer cells. Journal of Controlled Release, 329. pp. 413-433. ISSN 0168-3659

PDF 12855.pdf - Published Version Restricted to Registered users only Download (3MB) | Request a copy

Abstract

With the changing face of healthcare, there is a demand for drug delivery systems that have increased efficacy and biocompatibility. Nanotechnology derived drug carrier systems were found to be ideal candidates to meet these demands. Among the vast number of nanosized delivery systems, biomimetic nanoparticles have been researched at length. These nanoparticles mimic cellular functions and are highly biocompatible. They are also able to avoid clearance by the reticuloendothelial system which increases the time spent by them in the systemic circulation. Additionally, their low immunogenicity and targeting ability increase their significance as drug carriers. Based on their core material we have summarized them as biomimetic inorganic nanoparticles, biomimetic polymeric nanoparticles, and biomimetic lipid nanoparticles. The core then may be coated using membranes derived from erythrocytes, cancer cells, leukocytes, stem cells, and other membranes to endow them with biomimetic properties. They can be used for personalized therapy and diagnosis of a large number of diseases, primarily cancer. This review summarizes the various therapeutic approaches using biomimetic nanoparticles along with their applications in the field of cancer imaging, nucleic acid therapy and theranostic properties. A brief overview about toxicity concerns related to these nanoconstructs has been added to provide knowledge about biocompatibility of such nanoparticles

Actions (login required)

View Item