Stimuli-responsive and cellular targeted nanoplatforms for multimodal therapy of skin cancer

Padya, Bharath Singh and Pandey, Abhijeet and Pisay, Muralidhar and Koteshwara, KB and Hariharapura, Raghu Chandrashekar and Mutalik, Srinivas (2021) Stimuli-responsive and cellular targeted nanoplatforms for multimodal therapy of skin cancer. European Journal of Pharmacology, 890. pp. 1-20. ISSN 0014-2999

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Abstract

Interdisciplinary applications of nanopharmaceutical sciences have tremendous potential for enhancing pharmacokinetics, efficacy and safety of cancer therapy. The limitations of conventional therapeutic platforms used for skin cancer therapy have been largely overcome by the use of nanoplatforms. This review discusses various nanotechnological approaches experimented for the treatment of skin cancer. The review describes various polymeric, lipidic and inorganic nanoplatforms for efficient therapy of skin cancer. The stimuli-responsive nanoplatforms such as pH-responsive as well as temperature-responsive platforms have also been reviewed.Different strategies for potentiating the nanoparticles application for cancer therapy such as surface engineering,conjugation with drugs, stimulus-responsive and multimodal effect have also been discussed and compared with the available conventional treatments. Although, nanopharmaceuticals face challenges such as toxicity, cost and scale-up, efforts put-in to improve these drawbacks with continuous research would deliver exciting and promising results in coming days

Item Type: Article
Uncontrolled Keywords: Skin cancer; pH-responsive; Mitochondria-targeted; Hyperthermia; Temperature responsive; Nanoplatform
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 08 Sep 2021 10:36
Last Modified: 08 Sep 2021 10:36
URI: http://eprints.manipal.edu/id/eprint/157314

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