Synthesis, spectral characterization and α-amylase inhibition studies of Coumarin-hydrazone derivatives

Shetty, Shivaprasad M and Kumar, Anil N V and Kumar, Anil H S (2020) Synthesis, spectral characterization and α-amylase inhibition studies of Coumarin-hydrazone derivatives. Chemical Data Collections, 27. ISSN 2405-8300

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A series of nineteen molecules of Coumarin hydrazone derivatives have been synthesized. The purpose of the study was to investigate the anti-diabetic activity of the synthesized Coumarin derivatives by inhibition of α-amylase. The α-amylase enzyme was isolated from the microbial source Aspergillus Niger. The experiment was conducted by taking 5, 10, 50,100 μM of each of the compounds and Acarbose was taken as a positive control. The studies showed that compoundN’-(2,4-dichlorobenzylidene)-4-((4-methyl-2-oxo-2H�chromen-7-yl)oxy)butanehydrazide (5f) (IC50=114.6 μM), 4-((4-methyl-2-oxo-2H-chromen�7-yl)oxy)-N’-(4 nitrobenzylidene)butanehydrazide (5g) (IC50=193.5μM), 4-((4-methyl-2- oxo-2H-chromen-7-yl)oxy)-N’-(4-methylbenzylidene)butanehydrazide(5i) (IC50=128.9μM), N’-(1-(4-methoxyphenyl)ethylidene)-4-((4-methyl-2-oxo-2H-chromen-7-yl)oxy) butanehy�drazide (6d)((IC50=183.1μM)and N’-(1-(2,7-dichloro-8-nitroquinolin-4-yl)ethylidene)-4-((4- methyl-2-oxo-2H-chromen -7-yl)oxy)butanehydrazide (7e) (IC50=110.4μM)was showing better inhibition activity against the enzyme, in comparison with the standard (IC50=126.5 μM). The synthesized drug may be helpful to control the glucose level asα-amylase is one of the causes of increased sugar level in our body.

Item Type: Article
Uncontrolled Keywords: 7-hydroxy-4-methyl Coumarin Enzyme inhibition α-amylase
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 11 Nov 2021 09:52
Last Modified: 11 Nov 2021 09:52

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