pKa Determination of carvedilol by spectrophotometry

Ram, Aswatha HN and Rathnanand, Mahalaxmi (2021) pKa Determination of carvedilol by spectrophotometry. Research Journal of Pharmacy and Technology, 14 (5). pp. 2714-2716. ISSN 0974-3618

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Proper knowledge of the pKa value of a compound is of uttermost importance for understanding the behavior of a drug inside the body. The pKa value of Nonselective alpha-1 and beta-blocker Carvedilol shows controversies in literature, whereas values between 7.7 and 8.7 have been previously reported. In this research paper, the pKa value of Carvedilol was re-evaluated using UV-vis spectroscopy. The analytical wavelength used was 241nm. The obtained sigmoid pattern was non-linear fitted using the Boltzmann sigmoidal algorithm. The determined pKa was 7.77 ± 0.09. This value is in accordance with some of the literature publications. Since extensive statistics and multiple replicate experiments were performed, it is assumed that 7.8 is the true pKa value of Carvedilol.

Item Type: Article
Uncontrolled Keywords: Carvedilol; pKa; spectrophotometry.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Library
Date Deposited: 23 Sep 2021 08:56
Last Modified: 23 Sep 2021 08:56

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