3D Printing: A review on technology, role in novel dosage forms and regulatory perspective

Hemanth, KG and Hemamanjushree, S and Abhinaya, N and Pai, Girish K (2021) 3D Printing: A review on technology, role in novel dosage forms and regulatory perspective. Research Journal of Pharmacy and Technology, 14 (1). pp. 562-572. ISSN 0974-3618

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The existence of 3D printing (3DP) ways back to 1992, and its sound presence in the pharmaceutical industry was made in 2015 by the launch of 1st 3D printed drug, Spritam was manufactured by Aprecia Pharmaceuticals. Implementation of 3DP is escalating in the number of industries, including the pharmaceutical industry. The purpose of this review paper is to briefly discuss types of 3DP and their role in formulating novel dosage forms. Binder jet printing, VAT polymerization, powder bed fusion, and material extrusion are briefly explained along with an example of their implementation in the formulation of the dosage form. A few novel dosage forms which can bypass the first-pass metabolism and how 3D printing is useful in formulating them as been discussed. It also includes a comparison of the process of 3D printed tablets and conventional methods of manufacturing. The significance of 3D printing in novel dosage form and augmenting 3DP with hot-melt extrusion (HME) method is discussed. The regulatory concerns in adopting this technology on a large-scale are addressed. 3DP technology could rapidly print transdermal needles, buccal patches, and different shapes of vaginal rings and proved it can be a versatile tool in formulation technology. As the pharmaceutical industry involves stringent regulations, certain aspects need to be considered by regulatory authorities before implementing this tool into commercialscale manufacturing.

Item Type: Article
Uncontrolled Keywords: 3D printing; additive manufacturing; 3D scanner; novel dosage forms; HME; regulatory perspective.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 19 Oct 2021 09:14
Last Modified: 19 Oct 2021 09:14
URI: http://eprints.manipal.edu/id/eprint/157477

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