Astragalus species: Insights on its chemical composition toward pharmacological applications

Salehi, Bahare and Carneiro, Joara Nályda Pereira and Rocha, Janaína Esmeraldo and Coutinho, Henrique Douglas Melo and Braga, Maria Flaviana Bezerra Morais and Sharifi-Rad3,, Javad Sharifi-Rad3, and Semwal, Prabhakar and Painuli, Sakshi and Moujir, Laila Moujir and Machado, Victoria de Zarate and Janakiraman, S and Kumar, Anil N V and Martorell, Mique and Cruz-Martins, Natalia and Beyrouthy, Marc El and Sadaka, Carmen Astragalus species: Insights on its chemical composition toward pharmacological applications. Phytotherapy Research.. ISSN 0951-418X

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Abstract

Astragalus L. is widely distributed throughout the temperate regions of Europe, Asia, and North America. The genus is widely used in folk medicine and in dietary supplements, as well as in cosmetics, teas, coffee, vegetable gums, and as forage for animals. The major phytoconstituents of Astragalus species with beneficial properties are saponins, flavonoids, and polysaccharides. Astragalus extracts and their isolated components xhibited promising in vitro and in vivo biological activities, including antiaging, antiinfective, cytoprotective, antiinflammatory, antioxidant, antitumor, antidiabesity, and immune-enhancing properties. Considering their proven therapeutic potential, the aim of this work is to give a comprehensive summary of the Astragalus spp. and their active components, in an attempt to provide new insight for further clinical development of these xenobiotics. This is the first review that briefly describes their ethnopharmacology, composition, biological, and toxicological properties.

Item Type: Article
Uncontrolled Keywords: antidiabesity, antifungal, antimicrobial, antioxidant, antiparasitic, antitumor, antiviral, Astragalus, cytoprotective, folk medicine, radix Astragali, toxicity
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 29 Oct 2021 05:19
Last Modified: 29 Oct 2021 05:19
URI: http://eprints.manipal.edu/id/eprint/157527

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