Neuroprotective role of Allium cepa and Allium sativum on Hippocampus, striatum and Cerebral cortex in Wistar rats

*, Nayanatara Arunkumar and Hegde, Anupama and Kini, Rekha D and Blossom, Vandana and Nayak, Shyamala and Poojary, Roopesh (2021) Neuroprotective role of Allium cepa and Allium sativum on Hippocampus, striatum and Cerebral cortex in Wistar rats. Research Journal of Pharmacy and Technology, 14 (5). pp. 2406-2411. ISSN 09743618

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Abstract

Natural products are gaining much importance in light of the serious side effects posed by drugs of chemical origin. High intake of foods rich in antioxidants reduces the risk of neurodegenerative disorders. Traditionally, Allium sativum L.(garlic) and Allium cepa. L (onion) has received considerable attention for their therapeutic benefits around the globe. The present study assesses the free radical scavenging role of Allium sativum and Allium cepa in cerebral cortex, striatum, and hippocampus. Adult wistar rats of either sex were grouped as control group (Group I) treated with normal saline and the two experimental group were treated with the aqueous bulbous extracts of dehydrated Allium sativum (Group II) and Allium cepa (Group III) was considered as treated groups. Homogenates of hippocampus, striatum and cerebral cortex were analyzed for biochemical and neuronal analysis. LD50 value of these extracts in rats was found at a dose of 500 mg/kg BW. A Significant decline (P<0.05) in the MDA level was observed in the hippocampus, striatum and cerebral cortex in group II when compared to group III. Total antioxidant level, GSH, SOD level was significantly high (P<0.001) in the treated groups. Neuronal increase was significant in Group II (P < 0.01) when compared to Group III. Allium sativum and Allium cepa was found to have a challenging role in hampering oxidative stress in Hippocampus, striatum and cerebral cortex, the target regions in neurological disorders. However, a

Item Type: Article
Uncontrolled Keywords: Garlic, Onion, Neuronal count, GSH, SOD, Antioxidant, MDA
Subjects: Medicine > KMC Mangalore > Physiology
Medicine > KMC Mangalore > Anatomy
Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 17 Dec 2021 11:06
Last Modified: 17 Dec 2021 11:06
URI: http://eprints.manipal.edu/id/eprint/157662

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