Vitamin D in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects

Vyas, Navya and Kurian, Shilia Jacob and Manu, Mohan K and Saravu, Kavitha and Mukhopadhyay, Chiranjay and Rao, Mahadev and Miraj, Sonal Sekhar (2021) Vitamin D in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects. Journal of the American College of Nutrition, 40 (7). pp. 632-645. ISSN 0731-5724

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Abstract

Vitamin D deficiency (VDD) partly explains geographical differences in COVID-19 susceptibility,severity, and mortality. VDD among African-Americans, diabetics, hypertensive, and aged populations possibly explain the higher death rate, aggravated by cocooning. Vitamin D is pleiotropic,mediating bone metabolism, calcium homeostasis, and immune functions, whereas VDD is associated with inflammatory reactions and immune dysfunction, predisposing individuals to severe infections. Vitamin D modulates innate and adaptive immunity via the expression of genes that code antimicrobial peptides (AMPs). And the expression of cluster of differentiation (CD)14, the co-receptor for epidermal toll-like receptor (TLR)4. AMPs stimulate TLR2 in macrophages, increasing the conversion of vitamin D into its active form by cytochrome P450 27B1. Antiviral properties of vitamin D-induced AMPs can shift the polarization of the adaptive immune response from helper T cells (Th)1 to the more regulatory Th2 responses that suppress immune over-reactivity by preventing cytokine storm, which is already demonstrated during the Spanish flu episode. Vitamin D induces antiviral effects by both direct and indirect mechanisms via AMPs, immunomodulation,the interplay between major cellular and viral elements, induction of autophagy and apoptosis,variation of genetic and epigenetic factors. The crosstalk between vitamin D and intracellular signaling pathways may operate as a primary regulatory action on viral gene transcription. VDD may increase the likelihood of infection with enveloped viruses, including retrovirus, hepatitis, and dengue. Global data correlates severe VDD with COVID-19 associated coagulopathy, disrupted immune response and mortality, reduced platelet count, and prolonged prothrombin time, suggesting benefits from supplementation

Item Type: Article
Uncontrolled Keywords: Coronavirus; COVID-19; Immunity; Pandemic; SARSCoV-2; vitamin D
Subjects: Departments at MU > Public Health
Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Microbiology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Medicine > KMC Manipal > Pulmonary Medicine
Depositing User: KMC Library
Date Deposited: 25 Nov 2021 08:47
Last Modified: 25 Nov 2021 08:47
URI: http://eprints.manipal.edu/id/eprint/157749

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