Exploring the signature gut and oral microbiome in individuals of specific Ayurveda prakriti

Jnana, Apoorva and Tanwar, Ankit Singh and Brand, Angela and Thokur, Sreepathy Murali and Kapaettu, Satyamoorthy (2021) Exploring the signature gut and oral microbiome in individuals of specific Ayurveda prakriti. Journal of Biosciences, 46. pp. 1-20. ISSN 0250-5991

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Diagnosis and treatment of various diseases in Ayurveda, the Indian system of medicine, relies on ‘prakriti’ phenotyping of individuals into predominantly three constitutions, kapha, pitta and vata. Recent studies propose that microbiome play an integral role in precision medicine. A study of the relationship between prakriti – the basis of personalized medicine in Ayurveda and that of gut microbiome, and possible biomarker of an individual’s health, would vastly improve precision therapy. Towards this, we analyzed bacterial metagenomes from buccal (oral microbiome) and fecal (gut microbiome) samples of 272 healthy individuals of various predominant prakritis. Major bacterial genera from gut microbiome included Prevotella, Bacteroides and Dialister while oral microbiome included Streptococcus, Neisseria, Veilonella, Haemophilus, Porphyromonas and Prevotella. Though the core microbiome was shared across all individuals, we found prakriti specific signatures such as preferential presence of Paraprevotella and Christensenellaceae in vata individuals.A comparison of core gut microbiome of each prakriti with a database of ‘healthy’ microbes identified microbes unique to each prakriti with functional roles similar to the physiological characteristics of various prakritis as described in Ayurveda. Our findings provide evidence to Ayurvedic interventions based on prakriti phenotyping and possible microbial biomarkers that can stratify the heterogenous population and aid in precision therapy

Item Type: Article
Uncontrolled Keywords: Ayurveda; Gut microbiome; Oral microbiome; Prakriti; Precision medicine
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 25 Nov 2021 08:48
Last Modified: 25 Nov 2021 08:48
URI: http://eprints.manipal.edu/id/eprint/157751

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