Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine

Shetty, Seema and Evangelatos, Nikolaos and Vishwanath, Shashidhar and Kapaettu, Satyamoorthy and Brand, Angela (2021) Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine. Brazilian Journal of Microbiology, 52. pp. 1327-1339. ISSN 1517-8382

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Abstract

Purpose Chlamydial genital infections constitute significant sexually transmitted infections worldwide. The often asymptomatic status of C. trachomatis (CT) infections leads to an increased burden on human reproductive health, especially in middle- and low-income settings. Early detection and management of these infections could play a decisive role in controlling this public health burden. The objective of this review is to provide an insight into the evolution of diagnostic methods for CT infections through the development of new molecular technologies, emphasizing on -omics’ technologies and their significance as diagnostic tools both for effective patient management and control of disease transmission.Methods Narrative review of the diagnostic methodologies of CT infections and the impact of the introduction of -omics’ technologies on their diagnosis by review of the literature.Results Various methodologies are discussed with respect to working principles, required specifications, advantages, and disadvantages. Implementing the most accurate methods in diagnosis is highlighted as the cornerstone in managing CT infections.Conclusion Diagnostics based on -omics’ technologies are considered to be the most pertinent modalities in CT testing when compared to other available methods. There is a need to modify these effective and accurate diagnostic tools in order to render them more available and feasible in all settings, especially aiming on turning them to rapid point-of-care tests for effective patient management and disease control

Item Type: Article
Uncontrolled Keywords: Chlamydia trachomatis; Genital infections; Diagnostics; NAAT; Point of care · -omics
Subjects: Departments at MU > Public Health
Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Microbiology
Depositing User: KMC Library
Date Deposited: 25 Nov 2021 08:48
Last Modified: 25 Nov 2021 08:48
URI: http://eprints.manipal.edu/id/eprint/157752

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