Effect of Vortioxetine on Maximal electroshock (MES) induced seizures in Sprague Dawley rats

Kumar, Sharath C and Parida, Amrita and Kabirdev, * and Priyadarshini, Prachi and Manju, V (2021) Effect of Vortioxetine on Maximal electroshock (MES) induced seizures in Sprague Dawley rats. Research Journal of Pharmacy and Technology, 14 (8). pp. 4337-4340. ISSN 0974-3618

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Abstract

Aim: To investigate the antiepileptic activity of vortioxetine. Materials and method: Vortioxetine was screened for its antiepileptic activity in Sprague-Dawley rats using maximal electroshock model. 4 groups of rats (each 6 rats) were used. First group was administered distilled water, second group diazepam and the third and fourth groups were given vortioxetine 10mg/kg and 20mg/kg respectively. These drug were given 30 minutes before the animal was subjected to electroshock (150mA, 50Hz for 0.2 seconds). Results: Vortioxetine effectively reduced tonic hind limb extension (THLE) in the rats and the effect was statistically significant compared to the control group. The seizure duration was also significantly lower compared to the control. There was no substantial difference in the duration of seizures and THLE between the diazepam and vortioxetine group. However, the total seizure score of the vortioxetine group was not statistically significant compared to the control group. Conclusion: Vortioxetine has the potential to be clinically useful in treating epilepsy. Further detailed studies using other animal models and in humans are required to prove its efficacy in epilepsy

Item Type: Article
Uncontrolled Keywords: Anti-seizure; Antidepressant; Serotonin reuptake inhibitors; Anti-epileptic; Maximal electroshock
Subjects: Medicine > MMMC Manipal > Anatomy
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 27 Nov 2021 05:59
Last Modified: 27 Nov 2021 05:59
URI: http://eprints.manipal.edu/id/eprint/157770

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